Amoora rohituka (Roxb.) Wight & Arn.

Family: Meliaceae

Synonyms

Aphanamixis polystachya (Wall.) R. N. Parker

Family Synonyms

Common Names

Pitraj, Tiktaraj, Royena; Ratam, Beri-rata, Baidraj (Sylhet), Okhyang, KKhia (Mogh).

Local Availability

All over Bangladesh in forest and village thickets.

Worldwide Availability

India, Pakistan, Nepal, Bhutan, Myanmar and Sri Lanka

Botanical Description 25

Amoora rohituka (Roxb.) Wight & Arn. (Synonym: Aphanamixis polystachya (Wall.) R. N. Parker) is a medium-sized, evergreen tree with a dense, spreading, crown. Large leaves with 30-90 cm long; leaflet

Common Ethnobotanical Use 26

The bark of Amoora rohituka (Roxb.) is astringent; applied in spleen and liver diseases, tumours and abdominal complaints. Seeds are useful for refrigerant, laxative, anthelmintic; cures ulcers and lessens muscular pain. Seed oil is used as stimulating liniment in rheumatism. Fruits are beneficial for the treatment of enlarged spleen and liver in Khagrachari. Oil of seed is used to treat rheumatism and conjointly has pesticides character. Bark and seed of plant are beneficial for ulcer. Various parts of the plant have been reported to act as analgesic, antimicrobial, antioxidant, antitumor CNS depressant, hepatoprotective, laxative, membrane stabilizing activities

Chemical Constituents

Compound Name Compound in Plant Parts Reference
1,8-CineoleLeaf; Fruit1
beta-Caryophyllene Leaf; Fruit1
Stigmasterol14
beta-sitosterol14
DaucosterolBark16
NerolidolLeaf; Fruit1
delta-CadineneLeaf; Fruit1
(E,E)-alpha-farneseneLeaf; Fruit1
beta-BourboneneLeaf; Fruit1
beta-ElemeneLeaf; Fruit1
beta-GurjuneneLeaf; Fruit1
alpha-HumuleneLeaf; Fruit1
ValenceneLeaf; Fruit1
alpha-CadineneLeaf; Fruit1
SpathulenolLeaf; Fruit1
Caryophyllene oxideLeaf; Fruit1
alpha-MuuroleneLeaf; Fruit1
alpha-CopaeneLeaf; Fruit1
gamma-ElemeneLeaf; Fruit1
ArtemiseoleLeaf; Fruit1
trans-p-Menth-2-en-1-ol Leaf; Fruit1
Sabinene hydrateLeaf; Fruit1
Sabinyl acetateLeaf; Fruit1
delta-ElemeneLeaf; Fruit1
alpha-CubebeneLeaf; Fruit1
alpha-YlangeneLeaf; Fruit1
beta-PatchouleneLeaf; Fruit1
alpha-GurjuneneLeaf; Fruit1
alpha-SantaleneLeaf; Fruit1
alpha-GuaieneLeaf; Fruit1
allo-AromadendereneLeaf; Fruit1
gamma-GurjuneneLeaf; Fruit1
ViridifloreneLeaf; Fruit1
alpha-SelineneLeaf; Fruit1
gamma-CadineneLeaf; Fruit1
ElemolLeaf; Fruit1
LedolLeaf; Fruit1
Germacrene D-4-olLeaf; Fruit1
GlobulolLeaf; Fruit1
GuaiolLeaf; Fruit1
gamma-EudesmolLeaf; Fruit1
alpha-MuurololLeaf; Fruit1
beta-EudesmolLeaf; Fruit1
alpha-EudesmolLeaf; Fruit1
alpha-CadinolLeaf; Fruit1
alpha-BisabololLeaf; Fruit1
Benzyl benzoateLeaf; Fruit1
(Z)-LanceolLeaf; Fruit1
6beta,7beta-epoxyguai-4-en-3-one Stem Bark2, 5, 6
6beta,7beta-epoxy-4beta,5-dihydroxyguaianeStem Bark2, 5, 6
AmoorininStem Bark3
7-Keto-octadec-cis-11-enoic acidSeed4
Aphanamixoid ALeaf; Twig9
Aphanamixoid BLeaf; Twig9
Aphapolynin CFruit10
Aphapolynin DFruit10
Aphapolynin EFruit10
Aphapolynin FFruit10
Aphapolynin GFruit10
Aphapolynin HFruit10
Aphapolynin IFruit10
Aphanamolide BFruit; Seed10, 18
Polystanin AFruit11
Polystanin BFruit11
Polystanin CFruit11
Aphanamixoid C12
Aphanamixoid D12
Aphanamixoid E12
Aphanamixoid F12
Aphanamixoid G12
Rohituka 3Root13
Rohituka 7Root13
Nymania 1Root13
Rubrin GRoot13
PrieurianinRoot13
Aphanamixinin14
Aphanamixin14
Turraeanthin14
Amooranin14
PolystachinSeed15
Hispidin CSeed15
RohitukinSeed15
Rohitukin 12Seed15
Rohituka 5Seed15
Rohituka 6Seed15
Rohituka 13 Seed15
Rohituka 14Seed15
PolystachyolBark16
NudiposideBark16
Ergosta-4,6,8(14),22-tetraen-3-oneBark16
Aphapolynin AFruit17
Aphapolynin BFruit17
Aphanamolide ASeed18
Aphanalide AFruit19
Aphanalide BFruit19
Aphanalide CFruit19
Aphanalide DFruit19
Aphanalide EFruit19
Aphanalide FFruit19
Aphanalide GFruit19
Aphanalide HFruit19
Betulin-3beta-O-beta-D-xylopyranoside14
Polystanin DFruit11
2-methoxy-14-calamenenoneStem Bark7
8-C-Methyl-Quercetin-3-O-beta-D-xylopyranosideRoot8
Aphanamixoid H12
Aphanamixoid I12
Aphanamixoid J12
Aphanamixoid K12
Aphanamixoid L12
Aphanamixoid M12
Aphanamixoid N12
Aphanamixoid O12
Aphanamixoid P12
Aphataiwanin ARoot13
Aphataiwanin BRoot13
Aphataiwanin CRoot13
Aphataiwanin DRoot13
methyl-1 xi,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oateRoot13
2,3-dihydroxy-5-pregnan-16-oneRoot13
Aphananin14

Pharmacological Evidence

Plants Parts Extract Type Activity Reference
Leaf
Methanol CNS Depressant 24
Methanol Analgesic 24
Stem Bark
Petroleum Ether Breast Cancer 20
Ethyl Acetate; Dichloromethane Ehrlich-Lettre Ascites Carcinoma 21
Petroleum Ether; Dichloromethane; Methanol Antiulcerant 22
Petrol Ether; Dichloromethane; Methanol Antibacterial 23

References

  • 1 Aboutabl, E., El-Sakhawy, F., Fathy, M. and Megid, R. (2000) Composition and Antimicrobial Activity of the Leaf and Fruit Oils from Amoora rohituka Wigth. et Arn. Journal of essential oil research, 12, 635-638.
  • 2 Chowdhury, R., Hasan, C.M. and Rashid, M.A. (2003) Guaiane sesquiterpenes from Amoora rohituka. Phytochemistry, 62, 1213-1216.
  • 3 Agnihotri, V.K., Srivastava, S.D. and Srivastava, S.K. (1987) A new limonoid, amoorinin, from the stem bark of Amoora rohituka. Planta medica, 53, 298-299.
  • 4 Daulatabad, C. and Jamkhandi, S.A. (1997) A keto fatty acid from Amoora rohituka seed oil. Phytochemistry, 46, 155-156.
  • 5 Paritala, V., Chiruvella, K.K., Thammineni, C., Ghanta, R.G. and Mohammed, A. (2015) Phytochemicals and antimicrobial potentials of mahogany family. Revista Brasileira de Farmacognosia, 25, 61-83.
  • 6 Rashid, M.A., Haque, M.R., Sikder, M.A.A., Chowdhury, A.A., Rahman, M.S. and Hasan, C.M. (2015) Review on chemistry and bioactivities of secondary metabolites from some medicinal plants and microbes of Bangladesh. Bangladesh Pharmaceutical Journal, 17, 1-17.
  • 7 Habib, M.R., Islam, M.A.U. and Karim, M.R. (2016) Cytotoxic Compounds from Calotropis gigantea (Linn.) and Amoora rohituka (Roxb.). International Biological and Biomedical Journal, 2, 120-126.
  • 8 Jain, S.A. and Srivastava, S.K. (1985) 8-C-methyl-quercetin-3-O-β/-D-xylopyranoside, a New Flavone Glycoside from the Roots of Amoora rohituka. Journal of Natural Products, 48, 299-301.
  • 9 Cai, J.-Y., Zhang, Y., Luo, S.-H., Chen, D.-Z., Tang, G.-H., Yuan, C.-M., Di, Y.-T., Li, S.-H., Hao, X.-J. and He, H.-P. (2012) Aphanamixoid A, a potent defensive limonoid, with a new carbon skeleton from Aphanamixis polystachya. Organic letters, 14, 2524-2527.
  • 10 Zhang, Y., Wang, J.-S., Wang, X.-B., Gu, Y.-C., Wei, D.-D., Guo, C., Yang, M.-H. and Kong, L.-Y. (2013) Limonoids from the fruits of Aphanamixis polystachya (Meliaceae) and their biological activities. Journal of agricultural and food chemistry, 61, 2171-2182.
  • 11 Zhang, Y., Wang, J.-S., Wang, X.-B., Gu, Y.-C. and Kong, L.-Y. (2013) Polystanins A–D, four new protolimonoids from the fruits of Aphanamixis polystachya. Chemical and Pharmaceutical Bulletin, 61, 75-81.
  • 12 Cai, J.-Y., Chen, D.-Z., Luo, S.-H., Kong, N.-C., Zhang, Y., Di, Y.-T., Zhang, Q., Hua, J., Jing, S.-X. and Li, S.-L. (2013) Limonoids from Aphanamixis polystachya and their antifeedant activity. Journal of natural products, 77, 472-482.
  • 13 Lin, C.-J., Lo, I.-W., Lin, Y.-C., Chen, S.-Y., Chien, C.-T., Kuo, Y.-H., Hwang, T.-L., Liou, S.-S. and Shen, Y.-C. (2016) Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya. Molecules, 21, 1167.
  • 14 Shweta, S., Rani, W., Tapadiya, G. and Khadabadi, S. (2014) Aphanamixis polystachya (wall.) Parker-An Important Ethnomedicinal Plant. Int. J. Pharm. Sci. Rev. Res, 24, 25-28.
  • 15 Mulholland, D.A. and Naidoo, N. (1999) Limonoids from Aphanamixis polystacha. Phytochemistry, 51, 927-930.
  • 16 Sadhu, S.K., Phattanawasin, P., Choudhuri, M.S.K., Ohtsuki, T. and Ishibashi, M. (2006) A new lignan from Aphanamixis polystachya. Journal of Natural Medicines, 60, 258-260.
  • 17 Zhang, Y., Wang, J.-S., Wang, X.-B., Wei, D.-D., Luo, J.-G., Luo, J., Yang, M.-H. and Kong, L.-Y. (2011) Aphapolynins A and B, two new limonoids from the fruits of Aphanamixis polystachya. Tetrahedron letters, 52, 2590-2593.
  • 18 Yang, S.-P., Chen, H.-D., Liao, S.-G., Xie, B.-J., Miao, Z.-H. and Yue, J.-M. (2010) Aphanamolide A, a new limonoid from Aphanamixis polystachya. Organic letters, 13, 150-153.
  • 19 Wang, J.-S., Zhang, Y., Wang, X.-B. and Kong, L.-Y. (2012) Aphanalides A–H, ring A-seco limonoids from the fruits of Aphanamixis polystachya. Tetrahedron, 68, 3963-3971.
  • 20 Chan, L.L., George, S., Ahmad, I., Gosangari, S.L., Abbasi, A., Cunningham, B.T. and Watkin, K.L. (2011) Cytotoxicity effects of Amoora rohituka and chittagonga on breast and pancreatic cancer cells. Evidence-Based Complementary and Alternative Medicine, 2011.
  • 21 Habib, M.R., ISLAM, M.M. and Karim, M.R. (2011) Antitumour activity of Amoora rohituka Roxb. stem against Ehrlich ascites carcinoma in mice. Biharean Biologist, 5, 109-112.
  • 22 Chowdhury, R. and Rashid, R. (2003) Effect of the crude extracts of Amoora rohituka stem bark on gastrointestinal transit in mice. Indian journal of pharmacology, 35, 304-307.
  • 23 Chowdhury, R., Hasan, C.M. and Rashid, M.A. (2003) Antimicrobial activity of Toona ciliata and Amoora rohituka. Fitoterapia, 74, 155-158.
  • 24 Hossain, M.M., Biva, I.J., Jahangir, R. and Vhuiyan, M.M.I. (2009) Central nervous system depressant and analgesic activity of Aphanamixis polystachya (Wall.) parker leaf extract in mice. African journal of pharmacy and pharmacology, 3, 282-286.
  • 25 Yusuf, M., Begum, J., Hoque, M. and Choudhury, J. (2009) Medicinal plants of Bangladesh-Revised and enlarged. Bangladesh Coun. Sci. Ind. Res. Lab. Chittagong, Bangladesh, 794.
  • 26 Ghani, A. (1998) Medicinal plants of Bangladesh: chemical constituents and uses. Asiatic society of Bangladesh.