Annona reticulata L.

Family: Annonaceae

Synonyms

Family Synonyms

Common Names

Nona (Bengali) , Ramphal (India), Nona Ata (Bengali); Bullock’s heart (Bengali); Nu Nachhi (Marma); Bullock's heart(English) , Corazon (English)

Local Availability

Planted throughout the country

Worldwide Availability

Southeast Asia, Taiwan, India, Australia, West Africa, Belize, Chiapas, Costa Rica, Guatemala, Honduras, Nicaragua, Panama

Botanical Description 25

Annona reticulata L. is a small semideciduous tree. It’s leaves are of 12.5-20.3 cm long, membranous, oblong, lanceolate. Flowers 2-4, on lateral peduncles. Petals 6, valvate, in 2 series, narrow-oblo

Common Ethnobotanical Use 26

The bark of Annona reticulata L. is a powerful astringent and tonic. Leaves of this plant are used against inflammation, tumours and as a maturant. Leaves and seeds are insecticidal. Fruits are used as astringent; used in dysentery and intestinal worms. Traditionally the plant has been used for treating epilepsy, cardiac problem, parasite and worm infestations, constipation, bacterial infection, fever, ulcer and as insecticide. Bark is a powerful astringent and employed as a tonic whereas leaves are used for helminthiasis treatment

Chemical Constituents

Compound Name Compound in Plant Parts Reference
alpha-TerpineolLeaf10
beta-Caryophyllene Leaf10
(2E,6E)-Farnesyl acetateLeaf10
beta-BisaboleneLeaf10
SabineneLeaf10
gamma-TerpineneLeaf10
4-TerpineolFruit11
ThymolLeaf10
beta-ElemeneLeaf10
alpha-HumuleneLeaf10
Humulene epoxide IILeaf10
DopamineLeaf18
beta-PineneFruit11
alpha-PineneFruit11
beta-SesquiphellandreneLeaf10
alpha-MuuroleneLeaf; Root8
MyrceneFruit11
p-CymeneLeaf10
TerpinoleneLeaf10
PatchulaneBark9
allo-AromadendereneLeaf10
ElemolLeaf10
Germacrene D-4-olLeaf10
beta-EudesmolLeaf; Root8
Benzyl benzoateLeaf10
AnnoreticuinLeaf; Seed1, 3
IsoannoreticuinLeaf1
SalsolinolLeaf14
CoclaurineLeaf15
ReticulineRoot2, 13
Kaur-16-ene-19-oic acidBark6, 12
MolvizarinStem Bark4
Rolliniastatin-2Stem Bark4, 5
ReticullacinoneStem Bark4
CopaeneLeaf; Root; Bark8, 9
Rolliniastatin16
Squamosine16
BullatacinSeed; Bark3, 6
cis and trans-IsomurisoleninSeed3
SquamocinSeed3
AcetogeninsSeed17
Germacrene DFruit11
LimoneneFruit11
AnnomonicinLeaf5
SolaminLeaf5
SquamoneLeaf5
Annoreticuin-9-oneSeed; Leaf3, 5
cis-trans-BullactacinoneSeed3
SpathulenolLeaf; Root8
1H-cycloprop(e)azuleneBark9
ReticulatacinBark6
NorushinsunineRoot13
LiriodenineBark; Root6, 13
NeoannoninRoot13
BenzylisoquinolineSeed19
AporphineSeed19
alpha-PhellandreneLeaf10
trans-Sabinene hydrateLeaf10
PinocarvoneLeaf10
delta-TerpineolLeaf10
MyrtenolLeaf10
CuminaldehydeLeaf10
beta-CedreneLeaf10
SesquisabineneLeaf10
ar-CurcumeneLeaf10
ZingibereneLeaf10
(Ε)-gamma-BisaboleneLeaf10
ar-TurmeroneLeaf10
(6S,7R)-BisaboloneLeaf10
(Ε)-alpha-AtlantoneLeaf10
Adriamycin20
14-Hydroxy-25-desoxyrollinicinStem Bark7

Pharmacological Evidence

Plants Parts Extract Type Activity Reference
Bark
Petroleum Ether Analgesic 9
Petroleum Ether Antiinflammatory 9
Leaf
Methanol Breast Cancer 21
Petroleum Ether; Methanol; Aqueous Antibacterial 23
Methanol Antidiabetic 24
Root
Ethanol Lung Cancer 22
Ethanol Leukemia 22
Ethanol Breast Cancer 22

References

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  • 2 Gopinath, K., Govindachari, T., Pai, B. and Viswanathan, N. (1959) Konstitution von Reticulin, einem neuen Alkaloid aus Anona reticulata Linn. European Journal of Inorganic Chemistry, 92, 776-779.
  • 3 Chang, F.-R., Chen, J.-L., Chiu, H.-F., Wu, M.-J. and Wu, Y.-C. (1998) Acetogenins from seeds of Annona reticulata. Phytochemistry, 47, 1057-1061.
  • 4 Hisham, A., Sunitha, C., Sreekala, U., Pieters, L., De Bruyne, T., Van den Heuvel, H. and Claeys, M. (1994) Reticulacinone, an acetogenin from Annona reticulata. Phytochemistry, 35, 1325-1329.
  • 5 Chan, F.-R., Wu, Y.-C., Duh, C.-Y. and Wang, S.-K. (1993) Studies on the acetogenins of Formosan Annonaceous plants, II. Cytotoxic acetogenins from Annona reticulata. Journal of natural products, 56, 1688-1694.
  • 6 Saad, J.M., Hui, Y.-h., Rupprecht, J.K., Anderson, J.E., Kozlowski, J.F., Zhao, G.-x., Wood, K.V. and McLaughlin, J.L. (1991) Reticulatacin: a new bioactive acetogenin from Annona reticulata (Annonaceae). Tetrahedron, 47, 2751-2756.
  • 7 Etse, J.T. and Waterman, P.G. (1986) Chemistry in the Annonaceae, XXII. 14-Hydroxy-25-desoxyrollinicin from the stem bark of Annona reticulata. Journal of natural products, 49, 684-686.
  • 8 Jirovetz, L., Buchbauer, G., Shafi, R. and Saidutty, A. (1998) Analysis of the essential oils of leaves and roots of Annona reticulato (Annonaceae) from South-India. NUTRITION-VIENNA-, 22, 9-10.
  • 9 Chavan, M.J., Wakte, P.S. and Shinde, D.B. (2012) Analgesic and anti-inflammatory activities of the sesquiterpene fraction from Annona reticulata L. bark. Natural product research, 26, 1515-1518.
  • 10 Ogunwande, I.A., Ekundayo, O., Olawore, N.O. and Kasali, A.A. (2006) Essential oil of Annona reticulata L. leaves from Nigeria. Journal of Essential oil research, 18, 374-376.
  • 11 Pino, J.A., Marbot, R. and Fuentes, V. (2003) Characterization of volatiles in bullock's heart (Annona reticulata L.) fruit cultivars from Cuba. Journal of agricultural and food chemistry, 51, 3836-3839.
  • 12 Chavan, M.J., Kolhe, D.R., Wakte, P.S. and Shinde, D.B. (2012) Analgesic and Antiinflammatory Activity of Kaur‐16‐en‐19‐oic acid from Annona reticulata L. Bark. Phytotherapy Research, 26, 273-276.
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  • 17 Rahman, S.M., Rashedul, M., Rahman, S., Mosaiab, T., Ahmed, R. and Khatun, F.J.A.N.A.S. (2011) Antihyperglycemic studies with methanol extract of Annona reticulata L.(Annonaceae) and Carissa carandas L.(Apocynaceae) leaves in Swiss albino mice. 5, 218-222.
  • 18 Jamkhande, P.G., Wattamwar, A.S.J.J.o.T. and Medicine, C. (2015) Annona reticulata Linn.(Bullock's heart): Plant profile, phytochemistry and pharmacological properties. 5, 144-152.
  • 19 Maeda, U., Hara, N., Fujimoto, Y., Srivastava, A., Gupra, Y.K. and Sahai, M.J.P. (1993) N-fatty acyl tryptamines from Annona reticulata. 34, 1633-1635.
  • 20 Saad, J.M., Hui, Y.-h., Rupprecht, J.K., Anderson, J.E., Kozlowski, J.F., Zhao, G.-x., Wood, K.V. and McLaughlin, J.L.J.T. (1991) Reticulatacin: a new bioactive acetogenin from Annona reticulata (Annonaceae). 47, 2751-2756.
  • 21 Roham, P.H., Kharat, K.R., Mungde, P., Jadhav, M.A. and Makhija, S.J. (2016) Induction of Mitochondria Mediated Apoptosis in Human Breast Cancer Cells (T-47D) by Annona reticulata L. Leaves Methanolic Extracts. Nutrition and cancer, 68, 305-311.
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  • 23 Padhi, L., Panda, S., Satapathy, S. and Dutta, S. (2011) In vitro evaluation of antibacterial potential of Annona squamosa L. and Annona reticulata L. from Similipal Biosphere Reserve, Orissa, India. Journal of agricultural Technology, 7, 133-142.
  • 24 Rahman, S.M., Rashedul, M., Rahman, S., Mosaiab, T., Ahmed, R. and Khatun, F. (2011) Antihyperglycemic studies with methanol extract of Annona reticulata L.(Annonaceae) and Carissa carandas L.(Apocynaceae) leaves in Swiss albino mice. Adv Nat Applied Sci, 5, 218-222.
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