Ichnocarpus frutescens

Family: Apocynaceae

Synonyms

Family Synonyms

Common Names

Dudhi, Syamalota (Bengali), Tabu chi (Marma), Dudhnoi (Chakma), Bhutta ludi (Tanchangya), Black Creeper (English)

Local Availability

Throughout the country in scrubs.

Worldwide Availability

China, India, Southeast Asia, and Northern Australia

Botanical Description 25

Ichnocarpus frutescens is large shrub, has many branches, which hold white latex in its all parts. Leaves are acuminate or acute, 4.5 to 7.5 in length, elliptic-oblong. Flowers are greenish white, sma

Common Ethnobotanical Use 26

The roots of Ichnocarpus frutescens are used in fever, diabetes, skin troubles, dyspepsia, and stone in the bladder. Roots are also considered as the tonic, cooling, demulcent, tonic, diaphoretic and alternative. Stems and leaves are used in the decoction forms in fevers. In headaches, leaves are applied, also in wounds and sore between fingers. Tribes in Bangladesh uses root in dental caries and stems and leaves for scabies.

Chemical Constituents

Compound Name Compound in Plant Parts Reference
Quercetin 3-O-glucosideFlower5
LupeolStem3
beta-sitosterolStem3
Oleanolic acid9
LuteolinLeaf8
QuercetinFlower5
Vanillic acidLeaf8
D-MannitolLeaf4
KaempferolLeaf4
Protocatechuic acidLeaf8
VitexinLeaf8
ProanthocyanidinLeaf8
FriedelinStem3, 9
ApigeninLeaf8
Ursolic AcidRoot7
alpha-AmyrinStem3
IsovitexinLeaf8
Syringic acidLeaf8
Nonane9
Lupeol acetateStem3, 9
FriedelinolStem3, 9
2-Hydroxy-4-methoxy benzaldehydeRoot10
n-Butyl oleateStem1
TetratriacontadieneStem1
n-Nonadecanyl benzoateStem1
TrifolinLeaf4
n-Octyl tetracontaneStem1
Lanosteryl oleateStem6
Dotriacontanoic acid9
Sitosterol palmitate9
Ursolic acid acetateLeaf4
Sinapic acidLeaf8
6,8,8-Trimethylpentacosan-7-oneStem3
Menth-1(7)-en-9-olyl dodecanoateStem6
2-(4-Methylcyclohex-3-enyl)propyl dodecanoateStem6
Benzocosanyl arachidateStem1
alpha-L-Rhamnopyranosyl-(1→4)-beta-D-glucopyranosyl-(1→3)-alpha-amyrinStem2

Pharmacological Evidence

Plants Parts Extract Type Activity Reference
Leaf
Polyphenol Ehrlich-Lettre Ascites Carcinoma 12
Polyphenol Leukemia 12
Ethanol; Aqueous Antifungal 15
Polyphenol Antidiabetic 19
Hydroalcohol Antidiabetic 20
Ethanol; Aqueous Anticonvulsant 21
Root
Methanol Breast Cancer 11
Methanol Liver Cancer 11
Methanol Lung Cancer 11
Methanol Gastric Cancer 11
Hexane; Chloroform; Aqueous Antifungal 24
Ethanol Antifungal 17
Hexane; Chloroform; Aqueous Antibacterial 24
Ethanol Antibacterial 17
Aqueous Antidiabetic 18
Methanol Anticonvulsant 22
Methanol Analgesic 23
Whole Plant
Ethanol Ovarian Cancer 14

References

  • 1 Aggarwal, B., Ali, M., Singh, V. and Singla, R.K. (2010) Isolation and Characterization of Phytoconstituents from the Stems of Ichnocarpus frutescens. Chinese Journal of Natural Medicines, 8, 401-404.
  • 2 Minocha, P. and Tandon, R. (1980) A new triterpene glycoside from the stem of Ichnocarpus frutescens. Phytochemistry, 19, 2053-2055.
  • 3 Lakshmi, D., Rao, E. and Rao, D. (1985) Triterpenoid constituents of Ichnocarpus frutescens. Indian Drugs, 22, 552-553.
  • 4 Khan, M., Javed, K. and HASNAIN KHAN, M. (1995) Chemical Constituents of the Leaves of Ichnocarpus frutescens R. Br. Journal of the Indian Chemical Society, 72, 65-66.
  • 5 Singh, R.P. and Singh, R.P. (1987). INDIAN CHEMICAL SOC 92 ACHARYA PRAFULLA CHANDRA RD ATTN: DR INDRAJIT KAR/EXEC SEC, CALCUTTA 700009, INDIA, Vol. 64, pp. 715-716.
  • 6 Aggarwal, B., Singla, R.K., Ali, M., Singh, V., Igoli, J.O., Gundamaraju, R. and Kim, K.H. (2015) Triterpenic and monoterpenic esters from stems of Ichnocarpus frutescens and their drug likeness potential. Medicinal Chemistry Research, 24, 1427-1437.
  • 7 Pandurangan, A., Khosa, R. and Hemalatha, S. (2010) Chemical studies on the roots of Ichnocarpus frutescens. Der Pharma Chemica, 2, 222-224.
  • 8 Daniel, M. and Sabnis, S. (1978) Chemotaxonomical studies on Apocynaceae. Indian J. Exp. Biol, 16, 512-513.
  • 9 Verma, R., Singh, N. and Gupta, M. (1987) Triterpenoids of Ichnocarpus frutescens. Fitoterapia, 58, 271-272.
  • 10 Chaudhary, K., Aggarwal, B. and Singla, R.K. (2012) Ichnocarpus frutescens: A medicinal plant with broad spectrum. Indo Global Journal of Pharmaceutical Sciences, 2, 63-69.
  • 11 Kumar Singh, N. and Pratap Singh, V. (2014) Anticancer activity of the roots of Ichnocarpus frutescens R. Br. and isolated triterpenes. Pakistan journal of pharmaceutical sciences, 27.
  • 12 Kumarappan, C. and Mandal, S.C. (2007) Antitumor activity of polyphenolic extract of Ichnocarpus frutescens. Exp Oncol, 29, 94-101.
  • 13 Dash, D.K., Nayak, S.S., Samanta, S., Ghosh, T., Jha, T., Maiti, B.C. and Maity, T.K. (2007) Antitumor activity and antioxidant role of Ichnocarpus frutescens against Ehrlich ascites carcinoma in swiss albino mice. Natural Product Sciences, 13, 54-60.
  • 14 Thangarajan, S., Perumal, S., Chinthamony, A.R., Paramasivam, R., Balasubramanian, V., Martin, S. and Gopalakrishnan, V.K. (2013) Chemomodulatory effects of Ichnocarpus frutescens R. Br against 4-vinylcyclohexane induced ovarian cancer in swiss albino mice. Journal of Acute Disease, 2, 151-155.
  • 15 Anoop, B., Kuppast, I., Kumar, H.P., Onkarappa, R. and Goutham, S. (2011) STUDIES ON THE ANTIMICROBIAL ACTIVITY OF AQUEOUS AND ALCOHOLIC EXTRACTS OF ICHNOCARPUS FRUTESCENS LEAVES. International Journal of Chemical Sciences, 9, 251-254.
  • 16 Malathy, N. and Sini, S. (2009) Antimicrobial activities of Ichnocarpus frutescens (L.) R. Br. and Hemidesmus indicus R. Br. Roots. Ancient science of life, 28, 13.
  • 17 Angle, G.P. and Sardessai, Y. Antimicrobial activity of the roots of Ichnocarpus frutescens.
  • 18 Barik, R., Jain, S., Qwatra, D., Joshi, A., Tripathi, G.S. and Goyal, R. (2008) Antidiabetic activity of aqueous root extract of Ichnocarpus frutescens in streptozotocin-nicotinamide induced type-II diabetes in rats. Indian Journal of Pharmacology, 40, 19.
  • 19 Kumarappan, C.T., Rao, T.N. and Mandal, S.C. (2007) Polyphenolic extract of Ichnocarpus frutescens modifies hyperlipidemia status in diabetic rats. J Cell Mol Biol, 6, 175-187.
  • 20 Kumarappan, C. and Mandal, S.C. (2008) α-Glucosidase inhibitory activity and in vitro antioxidant activities of alcohol-water extract (AWE) of Ichnocarpus frutescens leaves. Medicinal Chemistry Research, 17, 219.
  • 21 Prathib, B. and Varghese, N.P. Anticonvulsant Activity of Ethanol and Aqueous Extracts of Ichnocarpus Frutescens leaves in Experimental Mice. tuberculosis, 11, 13.
  • 22 Singh, N.K., Laloo, D., Garabadu, D., Singh, T.D. and Singh, V.P. (2014) Ichnocarpus frutescens ameliorates experimentally induced convulsion in rats. International scholarly research notices, 2014.
  • 23 Pandurangan, A., Khosa, R. and Hemalatha, S. (2008) Anti-Inflammatory and Analgesic activity of roots of Ichnocarpus Frutescens. Pharmacologyonline, 1, 392-399.
  • 24 Neharkar, V., Gautam, G. and Pandhare, R. (2016) CARDIOPROTECTIVE POTENTIAL OF HYGROPHILA AURICULATA (L.) LEAVES METHANOLIC EXTRACT AND IT’S SUB-FRACTION AGAINST DOXORUBICIN INDUCED CARDIOTOXICITY IN RATS.
  • 25 Yusuf, M., Begum, J., Hoque, M. and Choudhury, J. (2009) Medicinal plants of Bangladesh-Revised and enlarged. Bangladesh Coun. Sci. Ind. Res. Lab. Chittagong, Bangladesh, 794.
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