Ixora coccinea L. 

Family: Rubiaceae

Synonyms

Family Synonyms

Common Names

Rangan, Ranjan (Bangla), Jungle-flame lxora (English), Santan (Indonesia), Rugmini (Hindi).

Local Availability

Cultivated in gardens throughout Bangladesh.

Worldwide Availability

The plant is established in the Philippines. Native of India

Botanical Description 27

Ixora coccinea is an erect and smooth ornamental shrub, growing to a height of 2 to 3 meters. Leaves are stalkless or on very short stalks, oblong, 5 to 9 centimeters long, heart-shaped or rounded at

Common Ethnobotanical Use 28

Roots are sedative and stomachic; used in hiccup, fever, gonorrhoea, diarrhoea and dysentery. The flowers are used in the treatment of dysentery, leucorrhoea, dysmenorrhoea, haemoptysis and catarrhal bronchitis. The leaves are used in diarrhoea. EtOH(50%) extract of aerial parts is spermicidal and CNS depressant.

Chemical Constituents

Compound Name Compound in Plant Parts Reference
2-PentylfuranRoot4
LupeolLeaf; Aerial; Flower1, 3, 5, 6, 7, 8, 9
StigmasterolAerial6, 8
Hexadecanoic acidRoot4, 5, 8
beta-sitosterolLeaf; Aerial; Flower1, 3, 6, 5, 7, 8
7-Hydroxy-6-methoxychromen-2-oneAerial6, 8
Linoleic acidRoot5, 8
Octadecanoic acidRoot4, 5, 8
MyricetinFlower8
Linalool acetateFlower9
alpha-CopaeneFlower9
CampesterolRoot4
CycloartenolFlower7, 8
Oleanolic acidFlower5, 7, 8, 9
beta-AmyrinRoot; Aerial2, 6, 8
Lignoceric acidRoot4
SqualeneRoot4
LuteolinAerial6, 8
QuercetinFlower8
Cyanidin-3-rutinosideLeaf5
Oleic acidAerial5, 6, 8
(+)-CatechinAerial1, 6, 8
(-)-EpicatecholAerial5, 6, 8
D-MannitolLeaf; Root3, 10
RutinFlower5, 8
gamma-SitosterolRoot4
KaempferolAerial1, 6, 8
Kaempferol-7-glucosideRoot2, 8
NicotiflorinFlower8
QuercitrinRoot; Leaf2, 5, 8, 11
beta-SesquiphellandreneRoot8
Bornyl acetateFlower9
CoumarinAerial6, 8
Di-n-octyl pthalateRoot2, 8
Ursolic AcidAerial; Flower1, 5, 6, 7, 8, 9, 14
alpha-AmyrinAerial6, 8
gamma-TocopherolRoot4
2,6-Dimethoxy PhenolRoot4
Geranyl acetateFlower9
Neryl acetateFlower9
Terpinyl acetateFlower9
Ethyl (E)-cinnamateFlower9
KaempferinLeaf5
Ixoratannin A-2Leaf1, 5, 12
9,12-Octadecadienoic acidRoot2, 8
KaempferitrinRoot; Aerial2, 6, 8
2-HeptanoneRoot4
Methyl-9-methyltetradecanoateRoot4
9-Octadecenoic acidRoot4
4,8,12,16-Tetramethylheptadecan-4-olideRoot4
Tricosanoic acidRoot4
13-DocosenamideRoot4
5,22-Cholestadien-24-ethyl-3beta-olRoot4
Octadecadienoic acidRoot5
Procyanidin A2Leaf5, 8
Cinnamtannin B1Leaf5, 8
Kaempferol-7-O-alpha-L-rhamnnosideAerial5, 6, 8
Betunolic acidAerial6, 8
Oleanonic acidAerial6, 8
6beta-Hydroxystigmast-4-en-3-oneAerial6, 8
alpha-Tocopheryl quinoneAerial6
CamptothecinLeaf13, 8
Biochanin AFlower8
DaidzeinFlower8
FormononetinFlower8
CypereneFlower9
delta9,11-Octadecadinoic acidRoot10
3-Acetyl ursolic acidAerial6, 8
IxoreneLeaf3, 8
Kaempferol-3,7-O-alpha-L-dirhamnosideLeaf5, 12

Pharmacological Evidence

Plants Parts Extract Type Activity Reference
Flower
Petroleum Ether; Ethyl Acetate; Methanol Cervical Cancer 15
Methanol; Aqueous Antibacterial 20
Methanol; Ethyl Acetate Analgesic 24
Leaf
Crude Antifungal 16
Methanol Antibacterial 17
Methanol Antibacterial 18
Hydroalcohol Antiasthmatic 19
Organic Antiulcerant 21
Methanol Cardioprotective 23
Ethanol Analgesic 25
Chloroform CNS Depressant 26
Root
Chloroform Anthelmintic 22

References

  • 1 Kharat, A., Nambiar, V., Tarkasband, Y. and Pujari, R. (2013) A review on phytochemical and pharmacological activity of genus Ixora. International journal of research in pharmacy and chemistry, 3, 628-635.
  • 2 Joshi, A., Surlikar, P. and Bhobe, M. (2013) Ixora coccinea Linn: phytochemical investigation. Int J Res Pharm Chem, 3, 691-696.
  • 3 Ikram, A., Versiani, M.A., Shamshad, S., Salman, K.A., Ali, S.T. and Faizi, S. (2013) Ixorene, a New Dammarane Triterpene from the Leaves of Ixora coccinea Linn. Records of Natural Products, 7, 302.
  • 4 Ghazali, N., Abdullah, N.A., Bakar, A. and Mohamad, N.K. (2014) GC-MS analysis of some bioactive components in the root extract of Ixora coccinea linn. Int J Pharm Bio Sci, 5, 197-203.
  • 5 Baliga, M.S. and Kurian, P.J. (2012) Ixora coccinea Linn.: Traditional uses, phytochemistry and pharmacology. Chinese journal of integrative medicine, 18, 72-79.
  • 6 Lee, C.-L., Liao, Y.-C., Hwang, T.-L., Wu, C.-C., Chang, F.-R. and Wu, Y.-C. (2010) Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea. Bioorganic & medicinal chemistry letters, 20, 7354-7357.
  • 7 Ragasa, C.Y., Tiu, F. and Rideout, J.A. (2004) New cycloartenol esters from Ixora coccinea. Natural product research, 18, 319-323.
  • 8 Dontha, S., Kamurthy, H. and Mantripragada, B. (2015) Phytochemical and Pharmacological Profile of Ixora: A Review. International Journal of Pharmaceutical Sciences and Research, 6, 567.
  • 9 Obuzor, G.U. and Nwakanma, G.U. (2011) CHEMICAL COMPOSITION OF ESSENTIAL OIL OF IXORA COCCINEA FLOWER FROM PORT HARCOURT, NIGERIA. International Journal of Academic Research, 3.
  • 10 Kartha, A.R.S. and Menon, K. (1943) The isolation and constitution of an acid from the root bark ofIxora coccinea (Linn.). Proceedings Mathematical Sciences, 17, 11-15.
  • 11 Bose, S., Maji, S. and Chakraborty, P. (2013) Quercitrin from Ixora coccinea leaves and its anti-oxidant activity. J Pharmaceut Sci Technol, 2, 72-74.
  • 12 Idowu, T.O., Ogundaini, A.O., Salau, A.O., Obuotor, E.M., Bezabih, M. and Abegaz, B.M. (2010) Doubly linked, A-type proanthocyanidin trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties. Phytochemistry, 71, 2092-2098.
  • 13 Saravanan, P. and Boopalan, E. (2011) Occurrence of Camptothecin an Anticancer Drug from Ixora coccinea Linn. International Journal of Applied Biology, 2, 30-34.
  • 14 Latha, P., Nayar, M., Singh, O., George, V., Panikkar, K. and Pushpangadan, P. (2001) Isolation of antigenotoxic ursolic acid from Ixora coccinea flowers. Actualidades Biologicas, 23, 21-24.
  • 15 Haridass, S., Sekar, S., Vijayan, R., Jayakumar, S., Thtmizharasu, S., Krishnamurthy, V. and Chidambaram, S.B. (2012) Relative antioxidant and cytotoxic activities of Ixora coccinea flower extracts. J. Pharm. Res, 5, 1403-1408.
  • 16 Chatterjee, P. (2014) Study of Antifungal Property in the Crude Leaf Extract of Ixora coccinea against Botrytis cinerea. International Journal of Pharmaceutical & Biological Archive, 5.
  • 17 Idowu, T.O., Ogundaini, A.O., Salau, A.O., Obuotor, E.M., Bezabih, M. and Abegaz, B.M. (2010) Doubly linked, A-type proanthocyanidin trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties. Phytochemistry, 71, 2092-2098.
  • 18 Annapurna, J., Amarnath, P., Kumar, D.A., Ramakrishna, S. and Raghavan, K. (2003) Antimicrobial activity of Ixora coccinea leaves. Fitoterapia, 74, 291-293.
  • 19 Gbeassor, M. (2011) Evaluation of Anti-asthmatic Activities of Ixora coccinea Linn (Rubiaceae). Journal of Pharmacology and Toxicology, 201, 1.
  • 20 Pulipati, S. (2012) A comparative antibacterial study of Ixora coccinea L. plants with red, orange, pink and white flowers. Asian Journal of Pharmaceutical Research and Health Care, 4.
  • 21 Arunachalam, G., Subramanian, N., Pazhani, G., Karunanithi, M. and Ravichandran, V. (2009) Phytochemical and anti-ulcer investigations of the fresh leaf extract of Ixora coccinea Linn (Rubiaceae) in albino rat model. Int J Pharm Sci, 1, 26-31.
  • 22 Surana, R., Aher, A., Pal, S. and Deore, U. (2011) Evaluation of anthelmintic activity of Ixora coccinea. International Journal of Pharmacy & Life Sciences, 2.
  • 23 Momin, F.N., Kalai, B.R., Shikalgar, T.S. and Naikwade, N.S. (2012) Cardioprotective effect of methanolic extract of Ixora coccinea Linn. leaves on doxorubicin-induced cardiac toxicity in rats. Indian journal of pharmacology, 44, 178.
  • 24 Aher, A., Pal, S. and Muke, S. (2013) Analgesic and Antiinflammatory activities of Ixora coccinea flower. Indian Drugs, 50, 64-67.
  • 25 Adnan, M., Ali, S., Al-Amin, M., Uddin, N., Muhammad, M., Shohel, M., Bhattacharjee, R., Hannan, J. and Das, B.K. (2014) Analgesic, anti-inflammatory and antipyretic effects of Ixora coccinea. Journal of basic and clinical physiology and pharmacology, 25, 423-428.
  • 26 Islam, M. (2016), East West University.
  • 27 Yusuf, M., Begum, J., Hoque, M. and Choudhury, J. (2009) Medicinal plants of Bangladesh-Revised and enlarged. Bangladesh Coun. Sci. Ind. Res. Lab. Chittagong, Bangladesh, 794.
  • 28 Ghani, A. (1998) Medicinal plants of Bangladesh: chemical constituents and uses. Asiatic society of Bangladesh.